Depression in epilepsy relationship to seizures and anticonvulsant therapy

Depression in epilepsy. Relationship to seizures and anticonvulsant therapy.

depression in epilepsy relationship to seizures and anticonvulsant therapy

Epilepsy is the syndrome of two or more unprovoked seizures that occur Drug- related considerations — Aspects of antiseizure drug therapy treatment of epilepsy was the Standard and New Antiepileptic Drugs (SANAD) trial []. . depression at diagnosis of epilepsy and at each follow-up visit [69]. Treating depression and epilepsy at the same time can be a challenge. Bupropion may increase the frequency of seizures. ter the seizure, the term “peri-ictal depression” is now used in the literature. .. et al: Depression in epilepsy: relationship to seizures and anticonvulsant therapy.

For example, in experimental settings, amitriptyline has been shown to reduce spike activity at lower concentrations. Data are insufficient to determine whether these proposed mechanisms are the definitive cause of the convulsant properties of antidepressants. In general, the risk should be considered similar in each of the TCAs.

Monoamine oxidase inhibitors are believed to have a relatively low risk of seizures.

The Epilepsy-Depression Connection

Trazodone is considered to have a low risk of seizures, although seizures have been reported with its use. Bupropion IR had the highest incidence of seizure 0. They have also shown efficacy in preventing manic and depressive episodes in bipolar patients. Prior to initiating treatment of depression in a patient with epilepsy, it is important to ascertain that the depressive episodes are not caused by changes to the antiepileptic drug regimen.

Depression in epilepsy. Relationship to seizures and anticonvulsant therapy.

For example, discontinuing carbamazepine, valproic acid, or lamotrigine—all of which have mood-stabilizing properties—can lead to depressive episodes. Lowering the dosage or discontinuing the drug, if feasible, will lead to symptom remission. Supportive therapy should be offered to patients newly diagnosed with epilepsy, as well as to their family members.

depression in epilepsy relationship to seizures and anticonvulsant therapy

In addition, supportive therapy can help eliminate misinformation about epilepsy and teach patients and their families how to cope. ECT has been shown to be well tolerated among epilepsy patients.

depression in epilepsy relationship to seizures and anticonvulsant therapy

Elevated levels carbamazepine levels were observed when the drug was given with fluoxetine, fluvoxamine, or nefazodone. As a result, prescribers may be hesitant to use antidepressants in epilepsy patients. Further research has shown that, at lower doses, antidepressants possess anticonvulsant properties and that, at therapeutic doses, the risk of seizure activity is minimal.

It is suggested that patients with epilepsy and depression be treated with psychotherapy; if medication is indicated, SSRIs are generally considered first line because of their safety, tolerability, and ADR profile. ECT is a viable treatment option for patients with severe depression and epilepsy who are unable to take antidepressants. In selecting an antidepressant to be used in a patient with epilepsy, consideration should be made with regard to drug-drug interactions with the antiepileptic drugs, the potential for seizure activity, and the prominent depressive symptoms exhibited by the patient.

depression in epilepsy relationship to seizures and anticonvulsant therapy

The co-morbidity of depression and epilepsy: The influence of comorbid depression on quality of life for people with epilepsy. Gilliam F, Kanner A. Treatment of depressive disorders in epilepsy patients. Accessed July 28, American Psychiatric Association; The noradrenergic action in antidepressant treatments: There are different types of seizures with various symptoms.

You might violently shake, lose consciousness, and fall to the floor.

Treatment of Depression in Patients With Epilepsy

Or you might lose awareness of your surroundings and stare for a few seconds. In some cases, they might recommend surgery or other treatments. Depression is a common mood disorder. There are different kinds of depression. Most people feel down from time to time. If you have depression, you may: It can also make it hard to enjoy life.

depression in epilepsy relationship to seizures and anticonvulsant therapy

If you have symptoms of depression, make an appointment with your doctor. They can provide treatment or refer you to a mental health professional.

depression in epilepsy relationship to seizures and anticonvulsant therapy

When does depression affect people with epilepsy? For some people with epilepsy, symptoms of depression act as an aura. An aura is a warning sign that a seizure is coming. You might also feel depressed for several days after a seizure. Or you may experience long-term depression.