Relationship between drug abuse and left ventricular hypertrophy

Left ventricular hypertrophy Disease Reference Guide -

Learn more about the causes and treatment of this heart condition in which Strategies to control blood pressure in left ventricular hypertrophy due . Do you use alcohol or caffeine? Journal of the American Medical Association. Tests and Procedures A-Z · Drugs and Supplements A-Z · Appointments. Relationship between anti-hypertensive drugs and LVH regression and reported % reductions of the left ventricular mass, while the use of ACE inhibitors. Left ventricular hypertrophy associated with chronic cocaine abuse. were enrolled in an inpatient drug rehabilitation program were considered for the study .

In particular, ACE inhibitors have shown promising cardio-protective effects in experimental models of hypertensive heart disease;22 specifically, these inhibitors improve micro-vascular ischemia, ventricular function and arrhythmias. Conversely, the occurrence of these events increased when cardiac hypertrophy increased or remained stable.

Treatments consisted of medication and lifestyle changes. For individuals who showed an improvement in LVH, the rate of cardiovascular events was 1. In the groups that experienced no change or a worsening in LVH, the rate of cardiovascular events was 6.

These researchers also noted that this association did not depend on the initial ventricular mass, clinical parameters or monitored baseline blood pressure. Their final conclusion was that for primary hypertension, the decrease in ventricular mass during treatment is a favorable prognostic marker for subsequent morbid events. Relationship between anti-hypertensive drugs and LVH regression With the exception of minoxidil and hydralazine, which are peripheral vasodilators, the other anti-hypertensive drugs provided full or partial LVH regression.

In the literature, there are few monotherapy treatment meta-analyses. In addition, different groups report contradictory results. The difference between different anti-hypertensive drugs regarding their ability to reverse LVH may be determined by neural and humoral factors. The findings of these three studies conflict with the findings of some previous meta-analyses, and as such, these researchers have suggested that the effects of anti-hypertensive drug must be evaluated individually on their important intermediate targets, such as LVH, with appropriate patient populations.

The extrapolation of the LVH regression effects based on the anti-hypertensive drug classification may lead to clinical mistakes and needs to be carefully reconsidered. For instance, our group investigated isoproterenol-induced LVH in albino rats, which typically leads to hypertrophy without an increase in the after-load, and reported LVH regression by gavage administration of enalapril15, 16, 28, 31 and verapamil.

Alpha-methyldopa, captopril, beta-blockers and calcium channel blockers promote the regression of hypertrophy, while other drugs, such as hydralazine and minoxidil, reduce blood pressure without influencing ventricular hypertrophy. The ratio of ventricular mass to pressure is often weak, even in relation to blood pressure monitored every 24 hours.

Anti-hypertensive drugs have different effects on ventricular hypertrophy regression

Intrinsic properties of anti-hypertensives on LVH regression: A decrease in cardiac mass may not depend only on daily arterial pressure measurement. They evaluated the genetic association of the Sokolow-Lyon voltage index and the Cornell product index, the septal thickness and the ventricular wall, ventricular dimensions and left ventricular mass in members of British households, all items were evaluated n pairs and together.

Chromosomes 10, 12 and 17 were the genetic loci involved and had the most important influence on LVH, as detected by the electrocardiogram. However, the quantitative differences in LVH, known as phenotypes, may also be the result of individual differences besides those produced by the various anti-hypertensive drugs i.

Current medical literature shows the direct relationship between LVH and mortality, as well as the relationship between LVH regression and decreasing mortality. The literature also provides evidence for hypertrophic variations in response to the effect of different anti-hypertensive drugs and differences in the hemodynamic patterns.

The role of oxidative stress and lipid peroxidation in ventricular remodeling induced by tobacco smoke exposure after myocardial infarction. A case of pseudo-hypertrophic cardiomyopathy: Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Hemodynamic, morphometric and autonomic patterns in hypertensive rats - Renin-Angiotensin system modulation.

Cold stress effects on cardiomyocytes nuclear size in rats: Rev Bras Cir Cardiovasc. Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress.

Fluoxetine effects on mitochondrial ultrastructure of right ventricle in rats exposed to cold stress.

Left ventricular hypertrophy - Diagnosis and treatment - Mayo Clinic

Myocardium tissue changes caused by electrical transthoracic discharges in rats. Endothelial and non-endothelial coronary blood flow reserve and left ventricular dysfunction in systemic hypertension. Profile of cardiovascular risk factors and mortality in patients with symptomatic peripheral arterial disease. Diastolic function predicts outcome after aortic valve replacement in patients with chronic severe aortic regurgitation.

The vital role of papillary muscles in mitral and ventricular function: Enalaprilat in the prevention of left ventricular hypertrophy induced by isoproterenol. Effects of the prolonged inhibition of the angiotensin-converting enzyme on the morphological and functional characteristics of left ventricular hypertrophy in rats with persistent pressure overload. Echocardiographic left ventricular hypertrophy in hypertension: Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension.

Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. Prevention of structural changes in the heart in hypertension by angiotensin converting enzyme inhibition.

Effect of verapamil on left ventricular hypertrophy induced by isoproterenol. Left ventricular hypertrophy in hypertension: Prognostic significance of serial changes in left ventricular mass in essential hypertension. Rationale, design, and methods.

Drugs & Addiction : Effects of Drug Addiction in Adolescents

A randomised trial against atenolol. Reversal of left ventricular hypertrophy in essential hypertension. A meta-analysis of randomized double-blind studies. Impact of alpha- versus beta-blockers on hypertensive target organ damage: Am J Hypertens ; Influence of the Angiotensin II antagonist valsartan on left ventricular hypertrophy in patients with essential hypertension. Effects of losartan on hypertension and left ventricular mass: J Hum Hypertens ; Time course of complete normalization of left ventricular hypertrophy during long-term antihypertensive therapy with angiotensin converting enzyme inhibitors.

Left ventricular hypertrophy associated with chronic cocaine abuse.

Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med ; Comparison of five antihypertensive monotherapies and placebo for change in left ventricular mass in patients receiving nutritional-hygienic therapy in the Treatment of Mild Hypertension Study TOMHS.

Effect of single-drug therapy on reduction of left ventricular mass in mild to moderate hypertension. Comparison of six antihypertensive agents. Effect of treatment of isolated systolic hypertension on left ventricular mass.

Prognostic significance of serial changes. Pathogenesis, detection, and prognosis. Left ventricular mass and cardiovascular morbidity in essential hypertension: J Am Coll Cardiol ; Are beta-blockers efficacious as first-line therapy for hypertension in the elderly? Reduction of cardiovascular risk by regression of electrocardiographic markers of left ventricular hypertrophy by the angiotensin-converting enzyme inhibitor ramipriL Circulation ; Effects of once-daily angiotensin-converting enzyme inhibition and calcium channel blockade-based antihypertensive treatment regimens on left ventricular hypertrophy and diastolic filling in hypertension: Effect of the direct renin inhibitor aliskiren, the angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy.

Rationale and study design. Nephrol Dial Transplant ;